Title : SAG/ROC2/Rbx2 is a novel activator protein-1 target that promotes c-Jun degradation and inhibits 12-O-tetradecanoylphorbol-13-acetate-induced neoplastic transformation.

Pub. Date : 2007 Apr 15

PMID : 17440073






7 Functional Relationships(s)
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1 SAG/ROC2/Rbx2 is a novel activator protein-1 target that promotes c-Jun degradation and inhibits 12-O-tetradecanoylphorbol-13-acetate-induced neoplastic transformation. Tetradecanoylphorbol Acetate jun proto-oncogene Mus musculus
2 SAG/ROC2/Rbx2 is a novel activator protein-1 target that promotes c-Jun degradation and inhibits 12-O-tetradecanoylphorbol-13-acetate-induced neoplastic transformation. Tetradecanoylphorbol Acetate jun proto-oncogene Mus musculus
3 TPA-mediated SAG induction was significantly reduced in JB6-Cl.41 cells overexpressing a dominant-negative c-Jun, indicating a requirement of c-Jun/AP-1. Tetradecanoylphorbol Acetate jun proto-oncogene Mus musculus
4 TPA-mediated SAG induction was significantly reduced in JB6-Cl.41 cells overexpressing a dominant-negative c-Jun, indicating a requirement of c-Jun/AP-1. Tetradecanoylphorbol Acetate jun proto-oncogene Mus musculus
5 TPA-mediated SAG induction was significantly reduced in JB6-Cl.41 cells overexpressing a dominant-negative c-Jun, indicating a requirement of c-Jun/AP-1. Tetradecanoylphorbol Acetate jun proto-oncogene Mus musculus
6 When overexpressed, SAG remarkably reduced both basal and TPA-induced c-Jun levels, whereas SAG small interfering RNA (siRNA) silencing increased substantially the levels of both basal and TPA-induced c-Jun. Tetradecanoylphorbol Acetate jun proto-oncogene Mus musculus
7 When overexpressed, SAG remarkably reduced both basal and TPA-induced c-Jun levels, whereas SAG small interfering RNA (siRNA) silencing increased substantially the levels of both basal and TPA-induced c-Jun. Tetradecanoylphorbol Acetate jun proto-oncogene Mus musculus