Pub. Date : 2007 Nov
PMID : 17427962
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Prostaglandin E2 induces vascular endothelial growth factor secretion in prostate cancer cells through EP2 receptor-mediated cAMP pathway. | Dinoprostone | vascular endothelial growth factor A | Homo sapiens |
| 2 | Prostaglandin E2 (PGE2) has been shown to induce expression of vascular endothelial growth factor (VEGF) and other signaling molecules in several cancers. | Dinoprostone | vascular endothelial growth factor A | Homo sapiens |
| 3 | Prostaglandin E2 (PGE2) has been shown to induce expression of vascular endothelial growth factor (VEGF) and other signaling molecules in several cancers. | Dinoprostone | vascular endothelial growth factor A | Homo sapiens |
| 4 | Prostaglandin E2 (PGE2) has been shown to induce expression of vascular endothelial growth factor (VEGF) and other signaling molecules in several cancers. | Dinoprostone | vascular endothelial growth factor A | Homo sapiens |
| 5 | Prostaglandin E2 (PGE2) has been shown to induce expression of vascular endothelial growth factor (VEGF) and other signaling molecules in several cancers. | Dinoprostone | vascular endothelial growth factor A | Homo sapiens |
| 6 | Treatment of prostate cancer cells with PGE2 (1 nM-10 microM) increased both VEGF secretion and cyclic adenosine monophosphate (cAMP) production. | Dinoprostone | vascular endothelial growth factor A | Homo sapiens |
| 7 | We further demonstrated that the adenylate cyclase activator forskolin and the cAMP anologue 8-bromo-cAMP mimicked the effects of PGE2 on VEGF secretion in PC-3 cells. | Dinoprostone | vascular endothelial growth factor A | Homo sapiens |
| 8 | We conclude that PGE2-induced VEGF secretion in prostate cancer cells is mediated through EP2-, and possibly EP4-, dependent cAMP signaling pathways. | Dinoprostone | vascular endothelial growth factor A | Homo sapiens |