Pub. Date : 2007 Mar
PMID : 17425581
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | In the limbic-prefrontal territory of the dorsal striatum, enkephalin inhibits the NMDA-evoked release of acetylcholine directly through micro-opioid receptors (MORs) located on cholinergic interneurons and indirectly through MORs of output neurons of striosomes. | Acetylcholine | proenkephalin | Rattus norvegicus |
2 | Accordingly, the direct enkephalin-MOR control of acetylcholine release was preserved after 6-hydroxydopamine treatment and lost after cocaine exposure. | Acetylcholine | proenkephalin | Rattus norvegicus |
3 | Accordingly, the indirect enkephalin-MOR control of acetylcholine release disappeared in the 6-hydroxydopamine situation but surprisingly, despite preservation of MORs in striosomes, disappeared after cocaine treatment. | Acetylcholine | proenkephalin | Rattus norvegicus |
4 | Showing that MORs of striosomes are still functional in this situation, the MOR agonist [D-Ala(2),N-Me-Phe(4),Gly(5)-ol]-enkephalin inhibited the NMDA-evoked release of acetylcholine after cocaine exposure. | Acetylcholine | proenkephalin | Rattus norvegicus |