Title : Aphidicolin, an inhibitor of DNA replication, blocks the TPA-induced differentiation of a human megakaryoblastic cell line, MEG-O1.

Pub. Date : 1991 Dec 15

PMID : 1742484






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 In TPA-treated cells, the activity of DNA polymerase alpha, a marker for cell growth, remained at the same level as in control cells. Tetradecanoylphorbol Acetate DNA polymerase alpha 1, catalytic subunit Homo sapiens
2 Aphidicolin, a specific inhibitor of DNA polymerase alpha, completely inhibited the differentiation induction of MEG-O1 cells with TPA measured by either GP IIb/IIIa expression or multinuclear cell formation. Tetradecanoylphorbol Acetate DNA polymerase alpha 1, catalytic subunit Homo sapiens