Pub. Date : 2007 Jul
PMID : 17412884
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Apomine enhances the antitumor effects of lovastatin on myeloma cells by down-regulating 3-hydroxy-3-methylglutaryl-coenzyme A reductase. | apomine | 3-hydroxy-3-methylglutaryl-CoA reductase | Homo sapiens |
| 2 | Apomine, a 1,1-bisphosphonate-ester with antitumor activity, has previously been reported to strongly down-regulate 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase), the rate-limiting enzyme in the mevalonate pathway responsible for the prenylation of proteins. | apomine | 3-hydroxy-3-methylglutaryl-CoA reductase | Homo sapiens |