Pub. Date : 2007 Aug 1
PMID : 17412768
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Role of CNT3 in the transepithelial flux of nucleosides and nucleoside-derived drugs. | Nucleosides | solute carrier family 28 member 3 | Homo sapiens |
| 2 | Role of CNT3 in the transepithelial flux of nucleosides and nucleoside-derived drugs. | Nucleosides | solute carrier family 28 member 3 | Homo sapiens |
| 3 | We examined the role of the concentrative nucleoside transporter CNT3 in the establishment of a transepithelial flux of natural nucleosides and their pharmacologically active derivatives in renal epithelial cell lines. | Nucleosides | solute carrier family 28 member 3 | Homo sapiens |
| 4 | hCNT3 was also identified in human kidney and its role in the transport of nucleosides was tested. | Nucleosides | solute carrier family 28 member 3 | Homo sapiens |
| 5 | In these cells, hCNT3 was inserted into the apical membrane, thus generating, as for PCT cells, a transepithelial flux of both nucleosides and nucleoside-derived drugs. | Nucleosides | solute carrier family 28 member 3 | Homo sapiens |
| 6 | In these cells, hCNT3 was inserted into the apical membrane, thus generating, as for PCT cells, a transepithelial flux of both nucleosides and nucleoside-derived drugs. | Nucleosides | solute carrier family 28 member 3 | Homo sapiens |
| 7 | However release to the opposite compartment was CNT3 dependent, not only in terms of absolute flux (much higher when an apical CNT3 transporter was active) but also regarding metabolic transformations of the apically absorbed nucleosides. | Nucleosides | solute carrier family 28 member 3 | Homo sapiens |
| 8 | However release to the opposite compartment was CNT3 dependent, not only in terms of absolute flux (much higher when an apical CNT3 transporter was active) but also regarding metabolic transformations of the apically absorbed nucleosides. | Nucleosides | solute carrier family 28 member 3 | Homo sapiens |
| 9 | These results underline a critical role of CNT3 in the renal reabsorption of nucleosides and their derivatives as well as in their intracellular metabolism. | Nucleosides | solute carrier family 28 member 3 | Homo sapiens |