Title : The ATM/ATR signaling effector Chk2 is targeted by Epstein-Barr virus nuclear antigen 3C to release the G2/M cell cycle block.

Pub. Date : 2007 Jun

PMID : 17409144

1 Functional Relationships(s)
Compound Name
Protein Name
1 Importantly, we show that the direct interaction of EBNA3C with Chk2, the ATM/ATR signaling effector, is responsible for the release of this nocodazole-induced G2/M arrest and that this interaction leads to the serine 216 phosphorylation of Cdc25c, which is sequestered in the cytoplasm by 14-3-3. Nocodazole checkpoint kinase 2 Homo sapiens