Pub. Date : 2007 Apr 15
PMID : 17404266
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Aggregated ursolic acid, a natural triterpenoid, induces IL-1beta release from murine peritoneal macrophages: role of CD36. | ursolic acid | interleukin 1 beta | Mus musculus |
| 2 | UA increased the protein release of IL-1beta, IL-6, and MIF, but not of TNF-alpha, in dose- and time-dependent manners. | ursolic acid | interleukin 1 beta | Mus musculus |
| 3 | The release of UA-induced IL-1beta was significantly inhibited by the inhibitors of p38 MAPK, MEK1/2, ATP-binding cassette transporter, and caspase-1. | ursolic acid | interleukin 1 beta | Mus musculus |
| 4 | Furthermore, UA induced intracellular ROS generation for IL-1beta production, which was suppressed by an antioxidant. | ursolic acid | interleukin 1 beta | Mus musculus |
| 5 | Pretreatment with an anti-CD36 Ab significantly suppressed IL-1beta release, and surface plasmon resonance assay results showed that UA bound to CD36 on macrophages. | ursolic acid | interleukin 1 beta | Mus musculus |
| 6 | In addition, the amount of IL-1beta released from UA-treated pMphi of CD36-deficient mice was markedly lower than that from those of wild-type mice. | ursolic acid | interleukin 1 beta | Mus musculus |
| 7 | Interestingly, UA was found to aggregate in culture medium, and the aggregates were suggested to be responsible for IL-1beta production. | ursolic acid | interleukin 1 beta | Mus musculus |
| 8 | administration of UA increased the levels of IL-1beta secretion and MPO activity in colonic mucosa of ICR mice. | ursolic acid | interleukin 1 beta | Mus musculus |
| 9 | Taken together, our results indicate that aggregated UA is recognized, in part, by CD36 on macrophages for generating ROS, thereby activating p38 MAPK, ERK1/2, and caspase-1, as well as releasing IL-1beta protein via the ATP-binding cassette transporter. | ursolic acid | interleukin 1 beta | Mus musculus |