Title : Role of thrombin exosites in inhibition by heparin cofactor II.

Pub. Date : 1992 Feb 25

PMID : 1740413






1 Functional Relationships(s)
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1 Interestingly, in the presence of glycosaminoglycans the maximal inhibition rate constants by HC with heparin and dermatan sulfate, respectively, were as follows: 30.0 x 10(7) and 60.5 x 10(7) for alpha-thrombin, 14.6 x 10(7) and 24.3 x 10(7) for epsilon-thrombin, and 0.017 x 10(7) and 0.034 x 10(7) M-1 min-1 for gamma T-thrombin. Dermatan Sulfate CD59 molecule (CD59 blood group) Homo sapiens