Title : Resveratrol inhibits IL-1 beta-induced stimulation of caspase-3 and cleavage of PARP in human articular chondrocytes in vitro.

Pub. Date : 2007 Jan

PMID : 17404069






3 Functional Relationships(s)
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1 Resveratrol inhibits IL-1 beta-induced stimulation of caspase-3 and cleavage of PARP in human articular chondrocytes in vitro. Resveratrol interleukin 1 beta Homo sapiens
2 In this article we investigated whether resveratrol is able to block the effects of IL-1beta, specifically the activation of caspase-3 and subsequent cleavage of poly (ADP-ribose) polymerase (PARP) in human articular chondrocytes. Resveratrol interleukin 1 beta Homo sapiens
3 Resveratrol significantly reduced the IL-1beta-induced inhibition of expression of cartilage-specific collagen type II and signal transduction receptor beta1-integrin in a time-dependent manner. Resveratrol interleukin 1 beta Homo sapiens