Pub. Date : 2007 Jan
PMID : 17404014
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Apoptotic effect of celecoxib dependent upon p53 status in human ovarian cancer cells. | Celecoxib | tumor protein p53 | Homo sapiens |
| 2 | To explore the importance of functional status of p53 in apoptosis by celecoxib in ovarian cancer cells, the cellular response to celecoxib was determined in SK-OV3 ovarian cancer cells with null type p53 and PA-1 with wild-type p53. | Celecoxib | tumor protein p53 | Homo sapiens |
| 3 | These results suggest that death receptor and mitochondria-mediated apoptotic pathways may be involved in celecoxib-induced apoptosis dependent upon the functional status of p53. | Celecoxib | tumor protein p53 | Homo sapiens |
| 4 | Our article demonstrated that the celecoxib effectively inhibited cell growth and induced apoptosis in human ovarian cancer cells with wild-type p53. | Celecoxib | tumor protein p53 | Homo sapiens |
| 5 | Thus, apoptotic effect by celecoxib seemed to be different dependent upon the functional status of p53. | Celecoxib | tumor protein p53 | Homo sapiens |