Title : Proteasome-regulated ERBB2 and estrogen receptor pathways in breast cancer.

Pub. Date : 2007 Jun

PMID : 17392524






1 Functional Relationships(s)
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1 In keeping with the observation that 20S reduction has little effect on mitogen-activated protein kinase kinase 1/2 (MEK1/2) signaling in either ER-positive or ERBB2-positive models, only the MEK-1/2 inhibitor AZD6244 consistently improved the antitumor activity of bortezomib. AZD 6244 mitogen-activated protein kinase kinase 1 Homo sapiens