Pub. Date : 2007 Jun
PMID : 17389624
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Enoxaparin but not unfractionated heparin causes a dose-dependent increase in plasma TGF-beta 1 during haemodialysis: a cross-over study. | Enoxaparin | transforming growth factor beta 1 | Homo sapiens |
| 2 | In this cross-over study, we compared the effects of enoxaparin and unfractionated heparin (UFH) used as anticoagulants during haemodialysis (HD) on plasma TGF-beta1 levels and some platelet activation markers: platelet-derived growth factor-AB (PDGF-AB), beta-thromboglobulin (beta-TG) and platelet factor-4 (PF-4). | Enoxaparin | transforming growth factor beta 1 | Homo sapiens |
| 3 | RESULTS: Pre-dialysis, TGF-beta1 levels tended to be lower in patients anticoagulated with enoxaparin compared with UFH [6.9 (3.3-21.9) ng/ml vs 8.4 (3.8-30.2) ng/ml, respectively; P = 0.05]. | Enoxaparin | transforming growth factor beta 1 | Homo sapiens |
| 4 | The 35% increase in plasma TGF-beta1 after 180 min of HD positively correlated with the enoxaparin dose/kg (r = 0.553, P = 0.008) and, interestingly, negatively with the baseline level of the cytokine (r = -0.544, P = 0.009). | Enoxaparin | transforming growth factor beta 1 | Homo sapiens |
| 5 | CONCLUSION: Enoxaparin, compared with UFH, induces a rapid overdialytic but not sustained increase in plasma TGF-beta1 levels. | Enoxaparin | transforming growth factor beta 1 | Homo sapiens |