Title : Molecular basis for substrate discrimination by glycine transporters.

Pub. Date : 2007 May 11

PMID : 17383967






2 Functional Relationships(s)
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1 There are two Na(+)/Cl(-)-dependent glycine transporters, GLYT1 and GLYT2, which control extracellular glycine concentrations and these transporters show differences in substrate selectivity and blocker sensitivity. Glycine glycoprotein alpha-galactosyltransferase 1 (inactive) Homo sapiens
2 In this report, we demonstrate that the LeuT(Aa) structure represents a good working model of the Na(+)/Cl(-)-dependent neurotransmitters and that differences in substrate selectivity can be attributed to a single difference of a glycine residue in transmembrane domain 6 of GLYT1 for a serine residue at the corresponding position of GLYT2. Glycine glycoprotein alpha-galactosyltransferase 1 (inactive) Homo sapiens