Pub. Date : 2007 Jun 22
PMID : 17382927
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The authors investigated the effects of propofol on EAAT3 (excitatory amino acid transporter 3) activity under oxidative stress induced by tert-butyl hydroperoxide (t-BHP), and the mediation of these effects by protein kinase C (PKC). | tert-Butylhydroperoxide | solute carrier family 1 member 1 | Rattus norvegicus |
| 2 | The authors investigated the effects of propofol on EAAT3 (excitatory amino acid transporter 3) activity under oxidative stress induced by tert-butyl hydroperoxide (t-BHP), and the mediation of these effects by protein kinase C (PKC). | tert-Butylhydroperoxide | solute carrier family 1 member 1 | Rattus norvegicus |
| 3 | The authors investigated the effects of propofol on EAAT3 (excitatory amino acid transporter 3) activity under oxidative stress induced by tert-butyl hydroperoxide (t-BHP), and the mediation of these effects by protein kinase C (PKC). | tert-Butylhydroperoxide | solute carrier family 1 member 1 | Rattus norvegicus |
| 4 | Exposure of these oocytes to t-BHP (1-20 mM) for 10 min dose-dependently decreased EAAT3 activity, and t-BHP (5 mM) significantly decreased the Vmax, but not the Km of EAAT3 for glutamate, and propofol (1-100 microM) dose-dependently reversed this t-BHP-attenuated EAAT3 activity. | tert-Butylhydroperoxide | solute carrier family 1 member 1 | Rattus norvegicus |
| 5 | Phorbol-12-myristate-13-acetate (a PKC activator), also abolished this t-BHP-induced reduction in EAAT3 activity, whereas staurosporine (a PKC inhibitor), significantly decreased EAAT3 activity. | tert-Butylhydroperoxide | solute carrier family 1 member 1 | Rattus norvegicus |
| 6 | Phorbol-12-myristate-13-acetate (a PKC activator), also abolished this t-BHP-induced reduction in EAAT3 activity, whereas staurosporine (a PKC inhibitor), significantly decreased EAAT3 activity. | tert-Butylhydroperoxide | solute carrier family 1 member 1 | Rattus norvegicus |