Pub. Date : 2007 Feb
PMID : 17381401
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | PURPOSE: We determined whether LPS-induced TLR4 assembly and activation are dependent on the sphingolipid metabolite ceramide, produced by acid sphingomyelinase following the initial binding of LPS to CD14. | Ceramides | toll like receptor 4 | Homo sapiens |
| 2 | CONCLUSION: Assembly and activation of the TLR4 receptor following LPS binding to CD14 requires the production of ceramide by acid sphingomyelinase. | Ceramides | toll like receptor 4 | Homo sapiens |