Title : N-acetyltransferase 2 slow acetylator genotype associated with adverse effects of sulphasalazine in the treatment of inflammatory bowel disease.

Pub. Date : 2007 Mar

PMID : 17377643






2 Functional Relationships(s)
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1 RESULTS: Eleven patients (16%) experienced adverse effects from SASP, including nine cases of sulfapyridine (SP) dose-related adverse effects and two cases of hypersensitivity (skin rash). Sulfapyridine aspartic peptidase retroviral like 1 Homo sapiens
2 CONCLUSIONS: The NAT2 gene polymorphism was not associated with susceptibility to IBD in Chinese populations, but the NAT2 slow acetylator genotypes were significantly associated with SP dose-related adverse effects of SASP in the treatment of IBD. Sulfapyridine aspartic peptidase retroviral like 1 Homo sapiens