Title : Insulin-like growth factor (IGF)-II regulates CCAAT/enhancer binding protein alpha expression via phosphatidyl-inositol 3 kinase in human hepatoblastoma cell lines.

Pub. Date : 2007 Sep 1

PMID : 17372916






3 Functional Relationships(s)
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1 LY294002 and wortmannin, specific inhibitors of PI3 kinase, and PD98059, a specific inhibitor of mitogen-activated protein (MAP) kinase, were used to examine the signaling pathway of C/EBPalpha upregulated by IGF-II. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one CCAAT enhancer binding protein alpha Homo sapiens
2 LY294002 and wortmannin suppressed expression of C/EBPalpha. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one CCAAT enhancer binding protein alpha Homo sapiens
3 LY294002 and wortmannin suppressed the promoter activity of C/EBPalpha while PD98059 did not, suggesting that activation of the promoter was mediated by PI3 kinase. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one CCAAT enhancer binding protein alpha Homo sapiens