Title : Reactivation of the p53 pathway as a treatment modality for KSHV-induced lymphomas.

Pub. Date : 2007 Apr

PMID : 17364023






2 Functional Relationships(s)
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1 Our results demonstrated that the KSHV latency-associated nuclear antigen (LANA) bound to both p53 and MDM2 and that the MDM2 inhibitor Nutlin-3a disrupted the p53-MDM2-LANA complex and selectively induced massive apoptosis in PEL cells. nutlin 3 LANA Human gammaherpesvirus 8
2 Our results demonstrated that the KSHV latency-associated nuclear antigen (LANA) bound to both p53 and MDM2 and that the MDM2 inhibitor Nutlin-3a disrupted the p53-MDM2-LANA complex and selectively induced massive apoptosis in PEL cells. nutlin 3 LANA Human gammaherpesvirus 8