Title : Premature aging in klotho mutant mice: cause or consequence?

Pub. Date : 2007 May

PMID : 17353153






1 Functional Relationships(s)
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1 Recent studies have identified that fibroblast growth factor 23 (Fgf-23) null mice and klotho hypomorphs could generate multiple premature aging-like features, including shortened lifespan, infertility, kyphosis, atherosclerosis, extensive soft tissue calcifications, skin atrophy, muscle wasting, T cell dysregulation, pulmonary emphysema, osteoporosis/osteopenia, abnormal mineral ion metabolism, and impaired vitamin-D homeostasis. Vitamin D klotho Mus musculus