Pub. Date : 2007 Jun
PMID : 17346885
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Furthermore, long-term morphine infusion up-regulated PKA and PKC protein expression in the spinal cord dorsal horn, while amitriptyline inhibited the increase in expression of phospho-PKA, PKCalpha, PKCbetaII, and PKCgamma. | Morphine | protein kinase C, gamma | Rattus norvegicus |
| 2 | Furthermore, long-term morphine infusion up-regulated PKA and PKC protein expression in the spinal cord dorsal horn, while amitriptyline inhibited the increase in expression of phospho-PKA, PKCalpha, PKCbetaII, and PKCgamma. | Morphine | protein kinase C, gamma | Rattus norvegicus |
| 3 | In morphine-tolerant rats, acute treatment with PKA inhibitor H89 and PKC inhibitor Go6805 attenuated morphine tolerance and the morphine-induced CSF glutamate and aspartate elevation, and induced trafficking of GLAST and GLT-1 from cytosol onto the cell surface. | Morphine | protein kinase C, gamma | Rattus norvegicus |
| 4 | In morphine-tolerant rats, acute treatment with PKA inhibitor H89 and PKC inhibitor Go6805 attenuated morphine tolerance and the morphine-induced CSF glutamate and aspartate elevation, and induced trafficking of GLAST and GLT-1 from cytosol onto the cell surface. | Morphine | protein kinase C, gamma | Rattus norvegicus |
| 5 | In morphine-tolerant rats, acute treatment with PKA inhibitor H89 and PKC inhibitor Go6805 attenuated morphine tolerance and the morphine-induced CSF glutamate and aspartate elevation, and induced trafficking of GLAST and GLT-1 from cytosol onto the cell surface. | Morphine | protein kinase C, gamma | Rattus norvegicus |
| 6 | These results show that acute amitriptyline treatment preserved morphine"s antinociceptive effect in morphine-tolerant rats; the mechanisms may be involved in inhibition of phospho-PKA and PKC expression, and thus inducing the GLAST and GLT-1 trafficking onto glial cell surface which enhances the EAA uptake from the synaptic cleft and reduces EAA concentration in the spinal CSF. | Morphine | protein kinase C, gamma | Rattus norvegicus |
| 7 | These results show that acute amitriptyline treatment preserved morphine"s antinociceptive effect in morphine-tolerant rats; the mechanisms may be involved in inhibition of phospho-PKA and PKC expression, and thus inducing the GLAST and GLT-1 trafficking onto glial cell surface which enhances the EAA uptake from the synaptic cleft and reduces EAA concentration in the spinal CSF. | Morphine | protein kinase C, gamma | Rattus norvegicus |