Title : The impact of pegvisomant treatment on substrate metabolism and insulin sensitivity in patients with acromegaly.

Pub. Date : 2007 May

PMID : 17341562






2 Functional Relationships(s)
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1 CONTEXT: Pegvisomant is a specific GH receptor antagonist that is able to normalize serum IGF-I concentrations in most patients with acromegaly. pegvisomant insulin like growth factor 1 Homo sapiens
2 RESULTS: After pegvisomant, IGF-I decreased, whereas GH increased (IGF-I, 621 +/- 82 vs. 247 +/- 33 microg/liter, P = 0.02; GH, 5.3 +/- 1.5 vs. 10.8 +/- 3.3 microg/liter, P = 0.02). pegvisomant insulin like growth factor 1 Homo sapiens