Title : Association of total plasma homocysteine with methylenetetrahydrofolate reductase genotypes 677C>T, 1298A>C, and 1793G>A and the corresponding haplotypes in Swedish children and adolescents.

Pub. Date : 2007 Apr

PMID : 17334642






3 Functional Relationships(s)
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1 The MTHFR 677C>T polymorphism was associated with increased tHcy concentrations in both the children and the adolescents (P<0.001 for both age groups) in both genders. thcy methylenetetrahydrofolate reductase Homo sapiens
2 The effect of MTHFR 1298A>C was studied separately in subjects with the 677CC and 677CT genotypes, and the 1298C allele was found to be associated with higher tHcy levels both when children were stratified according to 677C>T genotypes, and when using haplotype analyses and diplotype reconstructions. thcy methylenetetrahydrofolate reductase Homo sapiens
3 The major genetic impact on tHcy concentrations is attributable to the MTHFR 677C>T polymorphism. thcy methylenetetrahydrofolate reductase Homo sapiens