Title : Adult-onset hypothyroidism facilitates and enhances LTD: reversal by chronic nicotine treatment.

Pub. Date : 2007 Apr

PMID : 17331737






1 Functional Relationships(s)
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1 Chronic nicotine treatment (1 mg/kg, 2x day) of hypothyroid rats reversed hypothyroidism-induced enhancement and facilitation of LTD. Western blot analysis of the NMDA receptor subunits in the membranous fractions of hippocampal area CA1 neurons revealed that hypothyroidism reduced NR1 and increased NR2B without affecting NR2A protein levels. Nicotine carbonic anhydrase 1 Rattus norvegicus