Title : Effects of pioglitazone on suppressor of cytokine signaling 3 expression: potential mechanisms for its effects on insulin sensitivity and adiponectin expression.

Pub. Date : 2007 Mar

PMID : 17327450






2 Functional Relationships(s)
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1 Conversely, pioglitazone increased adiponectin secretion and STAT3 phosphorylation in fat tissue of db/db mice and in 3T3-L1 adipocytes. Pioglitazone signal transducer and activator of transcription 3 Mus musculus
2 These results suggest that pioglitazone exerts its effect to improve whole-body insulin sensitivity in part through the suppression of SOCS3, which is associated with the increase in STAT3 phosphorylation and adiponectin production in fat tissue. Pioglitazone signal transducer and activator of transcription 3 Mus musculus