Title : Role of tissue-plasminogen activator (t-PA) in a mouse model of neonatal white matter lesions: interaction with plasmin inhibitors and anti-inflammatory drugs.

Pub. Date : 2007 May 11

PMID : 17321054






4 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 With both low (0.1 mug) and high (5 mug) ibotenic acid doses, tissue-plasminogen activator (t-PA) is involved in cyst formation. Ibotenic Acid plasminogen activator, tissue Mus musculus
2 Intracerebral hrt-PA induced WM cystic lesions in t-PA(-/-) mice and had an additive effect when co-injected with high-dose ibotenic acid. Ibotenic Acid plasminogen activator, tissue Mus musculus
3 Thus, the t-PA-dependent effect of low-dose ibotenic acid on cyst formation appeared independent from plasmin activity or inflammation. Ibotenic Acid plasminogen activator, tissue Mus musculus
4 Conversely, a t-PA-dependent inflammatory process occurred with high-dose ibotenic acid. Ibotenic Acid plasminogen activator, tissue Mus musculus