Title : Anti-malarial agent artesunate inhibits TNF-alpha-induced production of proinflammatory cytokines via inhibition of NF-kappaB and PI3 kinase/Akt signal pathway in human rheumatoid arthritis fibroblast-like synoviocytes.

Pub. Date : 2007 Jun

PMID : 17314215






2 Functional Relationships(s)
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1 TNF-alpha-induced production of IL-1beta, IL-6 and IL-8 was hampered by treatment with the phosphatidylinositol 3 (PI3) kinase inhibitor LY294002, suggesting that inhibition of Akt activation might inhibit IL-1beta, IL-6 and IL-8 production induced by TNF-alpha. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one interleukin 1 beta Homo sapiens
2 TNF-alpha-induced production of IL-1beta, IL-6 and IL-8 was hampered by treatment with the phosphatidylinositol 3 (PI3) kinase inhibitor LY294002, suggesting that inhibition of Akt activation might inhibit IL-1beta, IL-6 and IL-8 production induced by TNF-alpha. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one interleukin 1 beta Homo sapiens