Title : Depletion of ceramides with very long chain fatty acids causes defective skin permeability barrier function, and neonatal lethality in ELOVL4 deficient mice.

Pub. Date : 2007 Feb 6

PMID : 17311087






1 Functional Relationships(s)
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1 We further showed that the absence of ELOVL4 results in depletion in the epidermis of ceramides with omega-hydroxy very long chain fatty acids (> or = C28) and accumulation of ceramides with non omega-hydroxy fatty acids of C26, implicating C26 fatty acids as possible substrates of ELOVL4. c26 fatty acids elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 4 Mus musculus