Title : (-)-Adrenaline elicits positive inotropic, lusitropic, and biochemical effects through beta2 -adrenoceptors in human atrial myocardium from nonfailing and failing hearts, consistent with Gs coupling but not with Gi coupling.

Pub. Date : 2007 Mar

PMID : 17295024






2 Functional Relationships(s)
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1 Activation of either coexisting beta1- or beta2 -adrenoceptors with noradrenaline or adrenaline, respectively, causes maximum increases of contractility of human atrial myocardium. Norepinephrine potassium calcium-activated channel subfamily M regulatory beta subunit 1 Homo sapiens
2 For comparison, beta1 -adrenoceptor-mediated effects of (-)-noradrenaline were investigated in the presence of ICI 118,551 (50 nM to block beta2 -adrenoceptors). Norepinephrine potassium calcium-activated channel subfamily M regulatory beta subunit 1 Homo sapiens