Pub. Date : 2007 Feb 1
PMID : 17289896
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | PURPOSE: The present study evaluated and compared the efficacy of pegvisomant and octreotide in blocking the growth hormone (GH) axis in humans based on pharmacodynamic biomarkers associated with the GH axis. | Octreotide | growth hormone 1 | Homo sapiens |
| 2 | PURPOSE: The present study evaluated and compared the efficacy of pegvisomant and octreotide in blocking the growth hormone (GH) axis in humans based on pharmacodynamic biomarkers associated with the GH axis. | Octreotide | growth hormone 1 | Homo sapiens |
| 3 | CONCLUSIONS: Pegvisomant at well-tolerated s.c. doses was considerably more efficacious than octreotide in suppressing the GH axis, resulting in substantial and sustained inhibition of circulating IGF-I, IGF-II, and IGFBP-3 concentrations. | Octreotide | growth hormone 1 | Homo sapiens |