Title : Influence of major structural features of tocopherols and tocotrienols on their omega-oxidation by tocopherol-omega-hydroxylase.

Pub. Date : 2007 May

PMID : 17284776






4 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Human cytochrome P450 4F2 (CYP4F2) catalyzes the initial omega-hydroxylation reaction in the metabolism of tocopherols and tocotrienols to carboxychromanols and is, to date, the only enzyme shown to metabolize vitamin E. Tocopherols cytochrome P450 family 4 subfamily F member 2 Homo sapiens
2 Human cytochrome P450 4F2 (CYP4F2) catalyzes the initial omega-hydroxylation reaction in the metabolism of tocopherols and tocotrienols to carboxychromanols and is, to date, the only enzyme shown to metabolize vitamin E. Tocopherols cytochrome P450 family 4 subfamily F member 2 Homo sapiens
3 These results indicate that CYP4F2-mediated tocopherol-omega-hydroxylation is a central feature underlying the different biological half-lives, and therefore biopotencies, of the tocopherols and tocotrienols. Tocopherols cytochrome P450 family 4 subfamily F member 2 Homo sapiens
4 These results indicate that CYP4F2-mediated tocopherol-omega-hydroxylation is a central feature underlying the different biological half-lives, and therefore biopotencies, of the tocopherols and tocotrienols. Tocopherols cytochrome P450 family 4 subfamily F member 2 Homo sapiens