Title : Thalidomide induces limb deformities by perturbing the Bmp/Dkk1/Wnt signaling pathway.

Pub. Date : 2007 May

PMID : 17283219






1 Functional Relationships(s)
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1 This leads to up-regulation of the Bmp target gene and Wnt antagonist Dickkopf1 (Dkk1) with subsequent inhibition of canonical Wnt/beta-catenin signaling and increased cell death as shown by trypan blue and terminal deoxynucleotidyl transferase-mediated nick end labeling staining. Trypan Blue bone morphogenetic protein 1 Homo sapiens