Title : Chk1 is required for spindle checkpoint function.

Pub. Date : 2007 Feb

PMID : 17276342






1 Functional Relationships(s)
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1 Here, we show that Chk1, a component of the DNA damage and replication checkpoints, protects vertebrate cells against spontaneous chromosome missegregation and is required to sustain anaphase delay when spindle function is disrupted by taxol, but not when microtubules are completely depolymerized by nocodazole. Nocodazole checkpoint kinase 1 Homo sapiens