Title : Induction of apoptosis and inhibition of telomerase activity by arsenic trioxide (As2O3) in endometrial carcinoma cells.

Pub. Date : 2007 Apr

PMID : 17275888






1 Functional Relationships(s)
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1 Coincident with the inhibition of growth, As2O3 also induced apoptosis in all cell lines as measured by the time-dependent increase in M30 antibody fluorescence (binds a caspase-cleaved epitope of cytokeratin 18) detected by flow cytometry, and reduced telomerase activity by decreasing the hTERT mRNA expression. Arsenic Trioxide telomerase reverse transcriptase Homo sapiens