Pub. Date : 1992 Jan 1
PMID : 1727384
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | We had previously shown that transfection of this plasmid into Chinese hamster ovary (CHO) cells results in the expression of MGMT and in increased cellular resistance to N-methyl-N"-nitro-N-nitrosoguanidine and 1-(2-chloroethyl)-1-nitrosourea (CNU) but not N-nitroso-N-ethylurea (ENU). | 1-(2-chloroethyl)-1-nitrosourea | methylated-DNA--protein-cysteine methyltransferase | Cricetulus griseus |
2 | We had previously shown that transfection of this plasmid into Chinese hamster ovary (CHO) cells results in the expression of MGMT and in increased cellular resistance to N-methyl-N"-nitro-N-nitrosoguanidine and 1-(2-chloroethyl)-1-nitrosourea (CNU) but not N-nitroso-N-ethylurea (ENU). | 1-(2-chloroethyl)-1-nitrosourea | methylated-DNA--protein-cysteine methyltransferase | Cricetulus griseus |
3 | Expression of MGMT increased the resistance to CNU about 6-fold in both cell lines, but the difference between the two cell lines attributable to the excision repair defect still persisted. | 1-(2-chloroethyl)-1-nitrosourea | methylated-DNA--protein-cysteine methyltransferase | Cricetulus griseus |