Title : Regulation of TRP channel TRPM2 by the tyrosine phosphatase PTPL1.

Pub. Date : 2007 May

PMID : 17251321






1 Functional Relationships(s)
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1 Inhibition of tyrosine phosphorylation with the tyrosine kinase inhibitors genistein or PP2 significantly reduced the increase in [Ca(2+)](i) observed after H(2)O(2) or TNFalpha treatment in TRPM2-expressing cells, suggesting that phosphorylation is important in TRPM2 activation. Genistein tumor necrosis factor Homo sapiens