Title : Isolated isoflavones do not affect the circulating insulin-like growth factor system in men at increased colorectal cancer risk.

Pub. Date : 2007 Feb

PMID : 17237315






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1 We conducted a randomized, placebo-controlled, double-blind crossover study to investigate the effect of an 8-wk isolated isoflavone supplementation (84 mg/d) on serum concentrations of total IGF-I, free IGF-I, total IGF-II, IGF binding protein (BP)-1, IGFBP-2, and IGFBP-3. Isoflavones insulin like growth factor 1 Homo sapiens
2 Interestingly, the change in serum IGF-I concentrations after isoflavone supplementation was negatively associated with serum equol concentrations (r=-0.49, P=0.002). Isoflavones insulin like growth factor 1 Homo sapiens
3 However, to our knowledge, this is the first study that suggests isoflavones might have an IGF-I lowering effect in equol producers only. Isoflavones insulin like growth factor 1 Homo sapiens