Title : Expression of rib-1, a Caenorhabditis elegans homolog of the human tumor suppressor EXT genes, is indispensable for heparan sulfate synthesis and embryonic morphogenesis.

Pub. Date : 2007 Mar 16

PMID : 17237233






1 Functional Relationships(s)
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Protein Name
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1 The proteins encoded by all of the five cloned human EXT family genes (EXT1, EXT2, EXTL1, EXTL2, and EXTL3), members of the hereditary multiple exostoses gene family of tumor suppressors, are glycosyltransferases required for the biosynthesis of heparan sulfate. Heparitin Sulfate exostosin glycosyltransferase 2 Homo sapiens