Title : TNF-alpha knockout and minocycline treatment attenuates blood-brain barrier leakage in MPTP-treated mice.

Pub. Date : 2007 Apr

PMID : 17234424






1 Functional Relationships(s)
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1 Compared with WT mice, TNF-alpha KO mice treated with MPTP showed reduced FITC-LA leakage, decreased numbers of activated microglia, and reduced proinflammatory cytokines (TNF-alpha and interleukin 1beta) associated with significant MPTP-induced DA neuron loss. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine interleukin 1 beta Mus musculus