Title : Retinol decreases beta-catenin protein levels in retinoic acid-resistant colon cancer cell lines.

Pub. Date : 2007 Apr

PMID : 17219422






3 Functional Relationships(s)
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1 The RXR pan-antagonist and RXRalpha siRNA reduced the ability of retinol to decrease beta-catenin protein levels. Vitamin A retinoid X receptor alpha Homo sapiens
2 The RXR pan-antagonist and RXRalpha siRNA reduced the ability of retinol to decrease beta-catenin protein levels. Vitamin A retinoid X receptor alpha Homo sapiens
3 These results indicate that retinol may reduce colon cancer cell growth by increasing the proteasomal degradation of beta-catenin via a mechanism potentially involving RXR. Vitamin A retinoid X receptor alpha Homo sapiens