Title : Metabolic regulation of SIRT1 transcription via a HIC1:CtBP corepressor complex.

Pub. Date : 2007 Jan 16

PMID : 17213307






2 Functional Relationships(s)
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1 Treatment with the glycolytic blocker 2-deoxyglucose (2-DG) decreases association of the redox sensor CtBP with HIC1, an inhibitor of SIRT1 transcription. ctbp HIC ZBTB transcriptional repressor 1 Homo sapiens
2 We propose that the reduction in transcriptional repression mediated by HIC1, due to the decrease of CtBP binding, increases SIRT1 expression. ctbp HIC ZBTB transcriptional repressor 1 Homo sapiens