Title : Pharmacology and surface electrostatics of the K channel outer pore vestibule.

Pub. Date : 2006

PMID : 17206516






3 Functional Relationships(s)
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1 In contrast, TEA block of another type of K channel (Kv2.1) was insensitive to solution ionic strength and these channels were resistant to block by gallamine. Tetraethylammonium potassium voltage-gated channel subfamily B member 1 Homo sapiens
2 Neutralizing either of two lysine residues in the outer vestibule of these Kv2.1 channels conferred ionic strength sensitivity to TEA block. Tetraethylammonium potassium voltage-gated channel subfamily B member 1 Homo sapiens
3 Kv2.1 channels with both lysines neutralized were sensitive to block by gallamine, and the ionic strength dependence of this block was greater than that for TEA. Tetraethylammonium potassium voltage-gated channel subfamily B member 1 Homo sapiens