Pub. Date : 2007 Feb
PMID : 17203211
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Arsenic trioxide induces apoptosis via the mitochondrial pathway by upregulating the expression of Bax and Bim in human B cells. | Arsenic Trioxide | BCL2 associated X, apoptosis regulator | Homo sapiens |
| 2 | As2O3-induced apoptosis is associated with reduced mitochondrial transmembrane potential (delta psi), enhanced generation of intracellular reactive oxygen species (ROS), release of cytochrome c and apoptosis-inducing factor (AIF) from mitochondria into cytoplasm, activation of caspases, and upregulation of Bax and Bim expression. | Arsenic Trioxide | BCL2 associated X, apoptosis regulator | Homo sapiens |