Title : Interleukin-1 beta-induced nitric oxide production in isolated rat pancreatic islets requires gene transcription and may lead to inhibition of the Krebs cycle enzyme aconitase.

Pub. Date : 1991 Dec

PMID : 1720090






1 Functional Relationships(s)
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1 Both Meth-arg and N alpha-p-tosyl-L-lysine chloromethyl ketone (0.1 mM), a protease inhibitor, could completely counteract the IL-1 beta-induced increases in nitrite production and inhibition of aconitase activity and glucose oxidation rates. omega-N-Methylarginine interleukin 1 beta Rattus norvegicus