Pub. Date : 2007 Jan 1
PMID : 17200364
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | EXPERIMENTAL DESIGN: Enhancement of temozolomide via methoxyamine and MPG overexpression was analyzed using in vitro assays, including 3-(4-5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium salt (MTS) assay, apoptosis via Annexin staining, and Western blotting for H2AX phosphorylation to quantitate DNA damage. | Temozolomide | N-methylpurine DNA glycosylase | Homo sapiens |
| 2 | PURPOSE: To improve the treatment of women with ovarian cancer, we are investigating the modulation of a prominent DNA-damaging agent, temozolomide, by manipulating the DNA base excision repair (BER) pathway via BER inhibitor, methoxyamine, and overexpression of N-methylpurine DNA glycosylase (MPG). | Temozolomide | N-methylpurine DNA glycosylase | Homo sapiens |
| 3 | PURPOSE: To improve the treatment of women with ovarian cancer, we are investigating the modulation of a prominent DNA-damaging agent, temozolomide, by manipulating the DNA base excision repair (BER) pathway via BER inhibitor, methoxyamine, and overexpression of N-methylpurine DNA glycosylase (MPG). | Temozolomide | N-methylpurine DNA glycosylase | Homo sapiens |
| 4 | Our results show that MPG-overexpressing IGROV-1 and IGROV-1mp53 cells are significantly more sensitive to the clinical chemotherapeutic temozolomide in combination with methoxyamine as assayed by cytotoxicity, apoptosis, and levels of DNA damage than either agent alone. | Temozolomide | N-methylpurine DNA glycosylase | Homo sapiens |