Pub. Date : 2007 Mar
PMID : 17194895
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Heparin cofactor II (HCII) has several biochemical properties that distinguish it from other serpins: (1) it specifically inhibits thrombin; (2) the mechanism of inhibition involves binding of an acidic domain in HCII to thrombin exosite I; and (3) the rate of inhibition increases dramatically in the presence of dermatan sulfate molecules having specific structures. | Dermatan Sulfate | serine (or cysteine) peptidase inhibitor, clade D, member 1 | Mus musculus |
| 2 | Heparin cofactor II (HCII) has several biochemical properties that distinguish it from other serpins: (1) it specifically inhibits thrombin; (2) the mechanism of inhibition involves binding of an acidic domain in HCII to thrombin exosite I; and (3) the rate of inhibition increases dramatically in the presence of dermatan sulfate molecules having specific structures. | Dermatan Sulfate | serine (or cysteine) peptidase inhibitor, clade D, member 1 | Mus musculus |
| 3 | Heparin cofactor II (HCII) has several biochemical properties that distinguish it from other serpins: (1) it specifically inhibits thrombin; (2) the mechanism of inhibition involves binding of an acidic domain in HCII to thrombin exosite I; and (3) the rate of inhibition increases dramatically in the presence of dermatan sulfate molecules having specific structures. | Dermatan Sulfate | serine (or cysteine) peptidase inhibitor, clade D, member 1 | Mus musculus |
| 4 | Studies with HCII knockout mice directly support the hypothesis that HCII interacts with dermatan sulfate in the arterial wall after endothelial injury and thereby exerts an antithrombotic effect. | Dermatan Sulfate | serine (or cysteine) peptidase inhibitor, clade D, member 1 | Mus musculus |
| 5 | Studies with HCII knockout mice directly support the hypothesis that HCII interacts with dermatan sulfate in the arterial wall after endothelial injury and thereby exerts an antithrombotic effect. | Dermatan Sulfate | serine (or cysteine) peptidase inhibitor, clade D, member 1 | Mus musculus |