Title : N1-substituted thymine derivatives as mitochondrial thymidine kinase (TK-2) inhibitors.

Pub. Date : 2006 Dec 28

PMID : 17181158






1 Functional Relationships(s)
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1 Moreover, two of the most potent TK-2 inhibitors (18 and 26b) that also inhibit HSV-1 TK were able to reverse the cytostatic activity of 1-(beta-D-arabinofuranosyl)thymine (Ara-T) and ganciclovir in HSV-1 TK-expressing OST-TK-/HSV-1 TK+ cell cultures. Ganciclovir thymidine kinase 2 Homo sapiens