Pub. Date : 2006 Dec 15
PMID : 17178882
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Sorafenib blocks the RAF/MEK/ERK pathway, inhibits tumor angiogenesis, and induces tumor cell apoptosis in hepatocellular carcinoma model PLC/PRF/5. | Sorafenib | heparan sulfate proteoglycan 2 | Homo sapiens |
| 2 | In this study, we investigated the in vitro effects of sorafenib on PLC/PRF/5 and HepG2 HCC cells and the in vivo antitumor efficacy and mechanism of action on PLC/PRF/5 human tumor xenografts in severe combined immunodeficient mice. | Sorafenib | heparan sulfate proteoglycan 2 | Homo sapiens |
| 3 | In the PLC/PRF/5 xenograft model, sorafenib tosylate dosed at 10 mg/kg inhibited tumor growth by 49%. | Sorafenib | heparan sulfate proteoglycan 2 | Homo sapiens |
| 4 | In mechanism of action studies, sorafenib inhibited the phosphorylation of both ERK and eIF4E, reduced the microvessel area (assessed by CD34 immunohistochemistry), and induced tumor cell apoptosis (assessed by terminal deoxynucleotidyl transferase-mediated nick end labeling) in PLC/PRF/5 tumor xenografts. | Sorafenib | heparan sulfate proteoglycan 2 | Homo sapiens |