Title : Effects of calcium-free solution, calcium antagonists, and the calcium agonist BAY K 8644 on mechanical responses of skeletal muscle from patients susceptible to malignant hyperthermia.

Pub. Date : 1991 Sep

PMID : 1716078






2 Functional Relationships(s)
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1 The purpose of this investigation was to determine if alteration in the function of the dihydropyridine receptor may in turn modify halothane-induced contractures in muscle bundles from patients susceptible to malignant hyperthermia (MH). Halothane calcium voltage-gated channel subunit alpha1 S Homo sapiens
2 These results on cut MH-susceptible human muscle bundles support the hypothesis that halothane-induced contracture in MH can be modified by the binding of Ca2+ agonists or antagonists to the dihydropyridine receptor. Halothane calcium voltage-gated channel subunit alpha1 S Homo sapiens