Title : Inhibitors of the FEZ-1 metallo-beta-lactamase.

Pub. Date : 2007 Feb 15

PMID : 17157014






1 Functional Relationships(s)
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1 Starting from benzohydroxamic acid (1) structure-activity studies led to the identification of selective inhibitors of the FEZ-1 MBL, e.g., 2,5-substituted benzophenone hydroxamic acid 17 has a K(i) of 6.1+/-0.7microM against the FEZ-1 MBL but does not significantly inhibit the IMP-1, BcII, CphA or L1 MBLs. 2,5-substituted benzophenone hydroxamic acid insulin like growth factor 2 mRNA binding protein 1 Homo sapiens